La hipertrofia muscular hereditaria: génesis de alelos dominantes negativos de la miostatina (GDF-8) Murina
- Authors
- A. Barroso, L.J. Royo, J. Cañón, S. Dunner
- Issue
- 96A-3 (191-198)
- Topic
- Animal production
- Keywords
- TGF‑β, myostatin, muscular hypertrophy, dominant negative gene
- Abstract
Myostatin is an extracellular negative regulator of muscle growth. It is a member of the growth factor family TGF‑β, having similar structural and functional characteristics. Based on these structural and functional characteristics we have designed several gene constructions in order to create a series of dominant negative alleles of murine myostatin. Our aim is to obtain double‑muscled calves in the first generation by mating a modified sire carrying a dominant negative allele with non‑modified cows.
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