Although Spanish borage is grown as vegetable, in other countries, the production of seeds is the main goal of the crop because those seeds are a rich source of Gamma‑linolenic acid (GLA), a precursor of prostaglandins. This species has an indeterminate growth and its seeds dehisce at maturity. These facts limit the harvesting process and seed yield decreases. A review of different methodologies assessed until now in order to obtain a better yield are presented. Also some alternatives to obtain GLA by means of biotechnology are described.