Penoxsulam is commonly-used in rice crop in North eastern Spain with excellent control against Echi - nochloa ssp. and with some effect on Cyperaceae, but it belongs to an herbicide group prone to develop resistant biotypes. The aim of this work was to test herbicide programmes alternative to penoxsulam to preserve the efficacy of the few available active ingredients. The work consisted of 6 trials. Located in three locations during three years (2011-2013). In each trial eight herbicide programmes were applied, in two replicates distributed randomly in the field. The results showed that, effectively, penoxsulam had a good control on Echinochloa spp. after applying oxadiazon presowing. The best two alternative programmes to control Echinochloa ssp. and cyperaceous weeds were: (1) oxadiazon presowing followed by an application of profoxydim at 1-3 leaves stages of the rice and a third treatment until rice tillering of bentazone + MCPA or halosulfuron-metil and (2) propanil + bispyribac-Na at 1-3 leaves stage of the rice, a second treatment until rice tillering of bentazone + MCPA controlling both Echinochloa spp. and cyperaceous weeds. The drawback of this second programme is that bispyribac-Na belongs to the same mode of action group as penoxsulam although to different chemical families. However, the results show that it is possible to control the target weeds with several herbicide combinations to prevent herbicide-resistance appearance.